| 當期課號 |
1856 |
Course Number |
1856 |
| 授課教師 |
周德璋 |
Instructor |
CHOU,TEH CHANG |
| 中文課名 |
有機合成化學 |
Course Name |
Organic Synthesis |
| 開課單位 |
應用化學系(四日)三A |
Department |
|
| 修習別 |
選修 |
Required/Elective |
Elective |
| 學分數 |
3 |
Credits |
3 |
| 課程目標 |
本課程的目標在於介紹有機合成化學的基本原理與現代有機合成技術給學生，使其能應用這些知識解決有機合成化學領域的問題。課程內容包含：有機化學基本反應、有機反應機構、有機反應原理、有機合成的設計與應用、合成實例的探討等。 |
Objectives |
The course covers basic organic reactions, such as reductions, oxidations, alkylations, etc. Chemistry in protecting group, organometallics and enolates is also involved. The mechanism of the important reactions will be illustrated in detail. |
| 教材 |
方俊民、何東英、徐希白、曾國輝 “有機化學(第二版)”藝軒圖書公司 |
Teaching Materials |
|
| 成績評量方式 |
4次120分鐘考試，每次佔25% |
Grading |
4 2-hour examinations, 25% each |
| 教師網頁 |
|
| 教學內容 |
1. 緒論
2. 有機反應型態
3. 官能基轉換
4. 立體化學（重溫）
5. 編制碳-碳單鍵
6. 編制碳-碳多重鍵
7. 編制環結構
8. 重排之合成應用
9. 有機合成：實例解說 |
Syllabus |
1. Introductory Remarks
Reasons for synthesis // What is the ideal synthesis // Basic background knowledge
2. Types of Organic Reactions
Substitution reactions // Addition reactions // Addition reactions // Condensation reactions // Cyclization (ring closure) // Coupling reactions // Fragmentation // Isomerization // Skeletal-Rearrangement Reactions // Ring contraction and ring expansion // Oxidation and reduction // Pericyclic reactions
3. Functional Group Transformations
Creation of carbon-heteroatom bonds // Protective groups
4. Stereochemistry (revisit)
Optical isomers // asymmetric induction // selectivity
5. Formation of Carbon-Carbon Single Bonds
Stabilized carbanions and related nucleophiles // organometallic reagents
6. Formation of Carbon-Carbon multiple Bonds
1,2-Elimination reactions // Wittig and related reactions // Fragmentation methods
7. Ring Formation
Cycloaddtion // cyclization
8. Synthetic Application of Rearrangements
9. Organic Synthesis: Examples |