| 當期課號 |
7186 |
Course Number |
7186 |
| 授課教師 |
周德璋 |
Instructor |
CHOU,TEH CHANG |
| 中文課名 |
高等有機化學 |
Course Name |
Advanced Organic Chemistry |
| 開課單位 |
應用化學系碩士班一A |
Department |
|
| 修習別 |
選修 |
Required/Elective |
Elective |
| 學分數 |
3 |
Credits |
3 |
| 課程目標 |
本課程之目的在提供學生對有機反應在結構及反應機構上較深入的了解。課程的內容著重於鍵結理論、立體化學、反應機構與數種代表反應之機構研究。 |
Objectives |
The purpose of this course is to provide the students the knowledge in advanced organic chemistry. The topics will include 1) basic physical organic chemistry; 2) stereochemistry; 3) basicity and acidity and 4) the basic organic mechnism related to the organic reactions. |
| 教材 |
M. B. Smith and J. March, “Advanced Organic Chemistry” 5th edition
講義 |
Teaching Materials |
M. B. Smith and J. March, “Advanced Organic Chemistry” 5th edition
hand-out |
| 成績評量方式 |
4次120分鐘考試，每次佔25% |
Grading |
4 2-hour examinations, 25% each |
| 教師網頁 |
|
| 教學內容 |
1. 結構、鍵結、分子
2. 立體化學
3. 芳香性
4. 有機反應與機制
5. 取代反應
發生於sp3碳上的親核性取代反應
發生於sp2碳上的親核性取代反應
發生於芳香環的親電性取代反應
6. 消去反應：Pi-鍵的形成
7. 加成反應
親電性加成反應
親核性加成反應
環加成
8. 羰基-位的取代反應
烷基化
烯醇與烯醇陰離子
克萊森縮合及相關反應
9. 分子骨架重排
碳-碳重排反應
碳-氧重排反應
碳-氮重排反應 |
Syllabus |
1. Structure, Bonding, and Molecules
2. Stereochemistry
3. Aromaticity
4. Organic Reactions and Mechanisms
5. Substitution Reactions
Substitution by Nucleophiles at sp3-Hybridized Carbon
Nucleophilic Substitution at sp2-Hybridized Carbon
Electrophilic Aromatic Substitution
6. Elimination Reactions
Pi-Bond Formation Reactions
7. Addition Reactions
Electrophilic Additions
Nucleophilic Additions
Cycloaddition Reactions
8. Substitution Alpha to Carbonyl Groups
Alkylation
Enolate Anions and Enols
The Claisen Condensation and Related Reactions
9. Skeletal-Rearrangement Reactions
Carbon-Carbon Rearrangements
Carbon-Oxygen Rearrangements Carbon-Nitrogen Rearrangements |