| 當期課號 |
7210 |
Course Number |
7210 |
| 授課教師 |
李瑜章 |
Instructor |
LI,YU JANG |
| 中文課名 |
不對稱合成 |
Course Name |
Asymmetric Synthesis |
| 開課單位 |
應用化學系碩士班一A |
Department |
|
| 修習別 |
選修 |
Required/Elective |
Elective |
| 學分數 |
3 |
Credits |
3 |
| 課程目標 |
本課程首先將複習立體化學的基本概念。然後以最新發表的期刊論文為例, 探討製備純掌性異構物之各種方法, 這些方法主要包括:
1.羰基之α-烷化和有催化劑之烷化
2.Aldol 反應
3.不對稱氧化反應
4.不對稱Diels-Alder反應及其他環化反應
5.不對稱催化氫化反應及其他還原反應
6.不對稱合成在合成天然物上的應用
7.以?為催化劑的生物合成反應 |
Objectives |
This course will first review key aspects of stereochemistry. The various methods for the preparation of single enantiomer will then be reviewed with the most recent published results from a variety of Journal literature. The following asymmetric chemical transformations will be emphasized:
1. α-alkylation and catalytic alkylation of carbonyl compounds
2. Adol reactions
3. Aymmetric oxidation
4. Aymmetric Diels-Alder and other cyclization reactions
5. Asymmetric catalytic hydrogenation and other reduction reactions.
6. Applications of asymmetric reactions in the synthesis of natural products
7. Enzymatic reactions. |
| 教材 |
黑板上課, 作業, 口頭報告 |
Teaching Materials |
chalk talk, home work , oral report |
| 成績評量方式 |
期中考30%, 期末考40%, 作業20%, 口頭報告10% |
Grading |
midterm 30%, final40%. homework 20%, oral report 10% |
| 教師網頁 |
|
| 教學內容 |
chapter1/ introduction.
chapter2/ Principles
chapter3/ Addition to carbonyl compounds
chapter4/ a-substitution using chiarl enolates
chapter5/ asymmetric aldol reactions
chapter6/ addition to c-c double bonds
chapter8/ rearrangements |
Syllabus |
chapter1/ introduction.
chapter2/ Principles
chapter3/ Addition to carbonyl compounds
chapter4/ a-substitution using chiarl enolates
chapter5/ asymmetric aldol reactions
chapter6/ addition to c-c double bonds
chapter8/ rearrangements |